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Common TitleA1444-040 (Sofosbuvir plus Daclatasvir) Industry
Official Title Daclatasvir plus Sofosbuvir for Previously Treated or Untreated Chronic HCV Infection.
Phase Phase II
ClinicalTrials.gov NCT01359644
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
IndustryBristol-Myers Squibb
References
- Sulkowski MS, Gardiner DF, Rodriguez-Torres M, et al. Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection. N Engl J Med. 2014;370:211-21.
Common TitleATOMIC Industry
Official Title The ATOMIC Study: A Multicenter, Open-label, Randomized, Duration Finding Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Following Oral Administration of PSI-7977 in Combination With Pegylated Interferon and Ribavirin in Treatment-Naive Patients With Chronic HCV Infection Genotype 1,4, 5, or 6
Phase Phase II
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
IndustryGilead Sciences
References
- Kowdley KV, Lawitz E, Crespo I, et al. Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial. Lancet. 2013;381:2100-7.
Common TitleBOSON Industry
Official Title Efficacy of Sofosbuvir plus Ribavirin with or without Peginterferon-alfa in Patients with Hepatitis C Virus Genotype 3 Infection and Treatment-Experienced Patients with Cirrhosis and Hepatitis C virus Genotype 2 Infection.
Phase Phase III
ClinicalTrials.gov NCT01962441
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
IndustryGilead Sciences
References
- Foster GR, Pianko S, Brown A, et al. Efficacy of sofosbuvir plus ribavirin with or without peginterferon-alfa in patients with hepatitis C virus genotype 3 infection and treatment-experienced patients with cirrhosis and hepatitis C virus genotype 2 infection. Gastroenterology. 2015;149:1462-70.
Common TitleEgyptian Ancestry Genotype 4 Industry
Official Title Sofosbuvir plus Ribavirin for the Treatment of Chronic Genotype 4 Hepatitis C virus Infection in Patients of Egyptian Ancestry.
Phase Phase II
ClinicalTrials.gov NCT01713283
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
IndustryGilead Sciences
References
- Ruane PJ, Ain D, Stryker R, et al. Sofosbuvir plus ribavirin for the treatment of chronic genotype 4 hepatitis C virus infection in patients of Egyptian ancestry. J Hepatol. 2015;62:1040-6.
Common TitleELECTRON: Arms 1-8 Industry
Official Title Nucleotide Polymerase Inhibitor Sofosbuvir plus Ribavirin for Hepatitis C
Phase Phase II
ClinicalTrials.gov NCT01260350
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
IndustryGilead Sciences
References
- Gane EJ, Stedman CA, Hyland RH, et al. Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C. N Engl J Med. 2013;368:34-44.
Common TitleELECTRON (Overview): Arms 1-22 Industry
Official Title Efficacy of Nucleotide Polymerase Inhibitor sofosbuvir plus the NS5A Inhibitor Ledipasvir or the NS5B Non-Nucleoside inhibitor GS-9669 Against HCV Genotype 1 Infection.
Phase Phase II
ClinicalTrials.gov NCT01260350
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
IndustryGilead Sciences
References
- Gane EJ, Stedman CA, Hyland RH, et al. Efficacy of nucleotide polymerase inhibitor sofosbuvir plus the NS5A inhibitor ledipasvir or the NS5B non-nucleoside inhibitor GS-9669 against HCV genotype 1 infection. Gastroenterology. 2014;146:736-43.
- Gane EJ, Stedman CA, Hyland RH, et al. Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C. N Engl J Med. 2013;368:34-44.
Common TitleFISSION Industry
Official Title Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection
Phase Phase III
ClinicalTrials.gov NCT01497366
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
IndustryGilead Sciences
References
- Lawitz E, Mangia A, Wyles D, et al. Sofosbuvir for previously untreated chronic hepatitis C infection. N Engl J Med. 2013;368:1878-87.
Common TitleFUSION Industry
Official Title Sofosbuvir for Hepatitis C Genotype 2 or 3 in Patients without Treatment Options
Phase Phase III
ClinicalTrials.gov NCT01604850
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
IndustryGilead Sciences
References
- Jacobson IM, Gordon SC, Kowdley KV, et al. Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options. N Engl J Med. 2013;368:1867-77.
Common TitleHCV Target: Renal Disease Non-Industry
Official Title Safety and Efficacy of Sofosbuvir-Containing Regimens in Hepatitis C-Infected Patients with Impaired Renal Function
ClinicalTrials.gov NCT01474811
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
Non-IndustryUniversity of Florida and University of North Carolina
References
- Saxena V, Koraishy FM, Sise ME, et al. Safety and efficacy of sofosbuvir-containing regimens in hepatitis C-infected patients with impaired renal function. Liver Int. 2016;36:807-16.
Common TitleLONESTAR-2 Industry
Official Title Sofosbuvir with Peginterferon-Ribavirin for 12 Weeks in Previously Treated Patients with Hepatitis C Genotype 2 or 3 and Cirrhosis
Phase Phase II
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
IndustryGilead Sciences
References
- Lawitz E, Poordad F, Brainard DM, et al. Sofosbuvir with peginterferon-ribavirin for 12 weeks in previously treated patients with hepatitis C genotype 2 or 3 and cirrhosis. Hepatology. 2015;61:769-75.
Common TitleNEUTRINO Industry
Official Title Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection.
Phase Phase III
ClinicalTrials.gov NCT01641640
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
IndustryGilead Sciences
References
- Lawitz E, Mangia A, Wyles D, et al. Sofosbuvir for previously untreated chronic hepatitis C infection. N Engl J Med. 2013;368:1878-87.
Common TitleNIAID SPARE Non-Industry
Official Title Sofosbuvir and Ribavirin for Hepatitis C Genotype 1 in Patients with Unfavorable Treatment Characteristics: a Randomized Clinical Trial
Phase Phase II
ClinicalTrials.gov NCT01441180
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
Non-IndustryNational Institute of Allergy and Infectious Diseases (NIAID)
References
- Osinusi A, Meissner EG, Lee YJ, et al. Sofosbuvir and ribavirin for hepatitis C genotype 1 in patients with unfavorable treatment characteristics: a randomized clinical trial. JAMA. 2013;310:804-11.
Common TitlePHOTON-1 Industry
Official Title Sofosbuvir and Ribavirin for Hepatitis C in Patients with HIV Coinfection
Phase Phase III
ClinicalTrials.gov NCT01667731
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
IndustryGilead Sciences
References
- Sulkowski MS, Naggie S, Lalezari J, et al. Sofosbuvir and ribavirin for hepatitis C in patients with HIV coinfection. JAMA. 2014;312:353-61.
Common TitlePHOTON-2 Industry
Official Title Sofosbuvir plus Ribavirin for Treatment of Hepatitis C Virus in Patients Co-Infected with HIV (PHOTON-2): A Multicentre, Open-Label, Non-randomised, Phase 3 Study
Phase Phase III
ClinicalTrials.gov NCT01783678
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
IndustryGilead Sciences
References
- Molina JM, Orkin C, Iser DM, et al. Sofosbuvir plus ribavirin for treatment of hepatitis C virus in patients co-infected with HIV (PHOTON-2): a multicentre, open-label, non-randomised, phase 3 study. Lancet. 2015;385:1098-106.
Common TitlePOSITRON Industry
Official Title Sofosbuvir for Hepatitis C Genotype 2 or 3 in Patients without Treatment Options
Phase Phase III
ClinicalTrials.gov NCT01542788
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
IndustryGilead Sciences
References
- Jacobson IM, Gordon SC, Kowdley KV, et al. Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options. N Engl J Med. 2013;368:1867-77.
Common TitlePROTON Industry
Official Title Sofosbuvir in Combination with Peginterferon alfa-2a and Ribavirin for Non-cirrhotic, Treatment-naive Patients with Genotypes 1, 2, and 3 Hepatitis C Infection: A Randomised, Double-Blind, Phase 2 Trial.
Phase Phase II
ClinicalTrials.gov NCT01188772
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
IndustryGilead Sciences
References
- Lawitz E, Lalezari JP, Hassanein T, et al. Sofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naive patients with genotypes 1, 2, and 3 hepatitis C infection: a randomised, double-blind, phase 2 trial. Lancet Infect Dis. 2013;13:401-8.
Common TitleQUANTUM Industry
Official Title Safety Study of Regimens of Sofosbuvir, GS-0938, and Ribavirin in Patients With Chronic Hepatitis C Infection (QUANTUM)
Phase Phase II
ClinicalTrials.gov NCT01435044
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
IndustryGilead Sciences
References
- Lalezari JP, Nelson DR, Hyland RH, et al. Once daily sofosbuvir plus ribavirin for 12 and 24 weeks in treatment-naive patients with HCV infection: the QUANTUM study. Presented at the 48th Annual Meeting of the European Association for the Study of the Liver, Amsterdam; April 24-28, 2013. Abstract 845.
Common TitleRetreatment of Sofosbuvir Failure
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedReferences
- Esteban R, Nyberg L, Lalezari J, et al. Successful retreatment with sofosbuvir-containing regimens for HCV genotype 2 or 3 infected patients who failed prior sofosbuvir plus ribavirin therapy. 49th Annual Meeting of the European Association for the Study of the Liver, London; April 9-13, 2014. Abstract O8.
Common TitleSofosbuvir for Genotype 1-4 in HIV Coinfection Industry
Official Title Sofosbuvir for Chronic Hepatitis C Virus Infection Genotype 1-4 in Patients Coinfected with HIV.
Phase Phase II
ClinicalTrials.gov NCT01565889
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
IndustryGilead Sciences
References
- Rodriguez-Torres M, Gaggar A, Shen G, et al. Sofosbuvir for chronic hepatitis C virus infection genotype 1-4 in patients coinfected with HIV. J Acquir Immune Defic Syndr. 2015;68:543-9.
Common TitleSofosbuvir for HCV Recurrence Following Liver Transplantation Industry
Official Title Sofosbuvir and Ribavirin for Treatment of Compensated Recurrent Hepatitis C Virus Infection after Liver Transplantation
Phase Phase II
ClinicalTrials.gov NCT01687270
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedCategories Resistance/Virological FailureTreatment-NaiveTreatment-Experienced
Funding
IndustryGilead Sciences
References
- Charlton M, Gane E, Manns MP, et al. Sofosbuvir and ribavirin for treatment of compensated recurrent hepatitis C virus infection after liver transplantation. Gastroenterology. 2015;148:108-17.
Common TitleSofosbuvir to Prevent Post-Transplant HCV Recurrence Industry
Official Title Sofosbuvir and Ribavirin prevent Recurrence of HCV Infection After Liver Transplantation: An Open-Label Study
Purpose / DescriptionThis open-label, phase 2 trial, multicenter trial enrolled 63 patients with chronic hepatitis C and compensated cirrhosis awaiting liver transplantation for hepatocellular cancer. Patients receive sofosbuvir plus ribavirin for up to 48 weeks while awaiting transplant (all patients received at least 12 weeks of therapy). Among the 61 treated patients, 46 underwent liver transplantation; the study analysis was performed on the 43 (93%) of 46 patients who underwent transplant and had an HCV RNA level less than 25 IU/ml at the time of transplant. The sofosbuvir plus ribavirin was discontinued approximately 24 hours prior to transplantation. At 12 weeks post-transplantation, 30 (70%) of 43 patients had undetectable HCV RNA levels. Overall, the treatment was well-tolerated and the most frequently reported adverse effects were faigure, headache, and anemia.
Phase Phase II
ClinicalTrials.gov NCT01559844
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
IndustryGilead Sciences
References
- Curry MP, Forns X, Chung RT, et al. Sofosbuvir and ribavirin prevent recurrence of HCV infection after liver transplantation: an open-label study. Gastroenterology. 2015;148:100-107.
Common TitleVALENCE Industry
Official Title Sofosbuvir and Ribavirin in HCV Genotypes 2 and 3
Phase Phase III
ClinicalTrials.gov NCT01682720
Treatments
Sofosbuvir

Sofosbuvir
Tradename:SovaldiOther Names:SOFClass:FDA-ApprovedFunding
IndustryGilead Sciences
References
- Zeuzem S, Dusheiko GM, Salupere R, et al. Sofosbuvir and ribavirin in HCV genotypes 2 and 3. N Engl J Med. 2014;370:1993-2001.