Elbasvir-Grazoprevir Zepatier
Glecaprevir-Pibrentasvir Mavyret
Ledipasvir-Sofosbuvir Harvoni
Ribavirin Copegus, Rebetol, Ribasphere
Sofosbuvir Sovaldi
Sofosbuvir-Velpatasvir Epclusa
Sofosbuvir-Velpatasvir-Voxilaprevir VoseviSection Navigation
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- Module 5 Overview
Treatment of Hepatitis C Infection - 0%Lesson 1
Simplified HCV Treatment for All HCV GenotypesActivities- 0%Lesson 2
Retreatment of Patients with Prior HCV Treatment ExperienceActivities- 0%Lesson 3
Monitoring During and After HCV TreatmentTreatment of Hepatitis C Infection Overview4th Edition
Module Core Competency
Apply Evidence-Based Treatment for Hepatitis C Infection
Target Audience
Reviews simplified HCV treatment for all HCV genotypes and how to treat persons with prior HCV treatment experience, cirrhosis, or acute HCV infection.Editors
H. Nina Kim, MD, MSc,H. Nina Kim, MD, MSc
Professor of Medicine
Division of Allergy & Infectious Diseases
University of WashingtonDisclosures: NoneMaria A. Corcorran, MD, MPHMaria A. Corcorran, MD, MPH
Assistant Professor
Division of Allergy & Infectious Diseases
University of WashingtonDisclosures: NoneFree CNE/CME
Available in theModule Lessons
1Lesson 1 Simplified HCV Treatment for All HCV Genotypes
- Learning Objectives
- Summarize the eligibility criteria for the American Association for the Study of Liver Disease/Infectious Diseases Society of America (AASLD/IDSA) simplified HCV treatment algorithm
- Discuss how to assess liver fibrosis, including identifying decompensated cirrhosis
- List the direct-acting antiviral (DAA) treatment regimens recommended as part of the AASLD/IDSA simplified guidance
- Describe on-treatment monitoring for adults during HCV treatment using the simplified AASLD/IDSA guidance
- Describe appropriate post-treatment monitoring for adults after completing HCV treatment
- Quick ReferenceSimplified HCV Treatment for All HCV Genotypes Core Concepts
- Introduction
- Eligibility for Simplified HCV Treatment: Initial Assessment
- Simplified Treatment: Pretreatment Assessment for Patients without Cirrhosis
- Recommended Simplified Treatment Regimens for Patients without Cirrhosis
- Monitoring on and after HCV Treatment in Patients without Cirrhosis
- Simplified Treatment: Pretreatment Assessment for Patients with Compensated Cirrhosis
- Recommended Simplified Treatment Regimens for Patients with Compensated Cirrhosis
- Monitoring On and After Treatment for Patients with Compensated Cirrhosis
- Treatment Interruptions
- Summary Points
2Lesson 2 Retreatment of Patients with Prior HCV Treatment Experience
- Learning Objectives
- Discuss the approach to retreatment of patients with chronic hepatitis C in the direct-acting antiviral (DAA) era
- List the preferred therapeutic combinations for retreatment in persons with prior sofosbuvir-containing regimens
- Describe recommended options for retreatment in persons with prior treatment with elbasvir-grazoprevir
- Review preferred retreatment options for persons with prior treatment with glecaprevir-pibrentasvir
- Summarize options for persons with multiple prior DAA treatment failures
- Quick ReferenceRetreatment of Patients with Prior HCV Treatment Experience Core Concepts
3Lesson 3 Monitoring During and After HCV Treatment
- Learning Objectives
- List the recommended monitoring for treatment efficacy and safety in adults receiving HCV therapy
- Discuss monitoring for hepatitis B virus reactivation during HCV therapy
- Summarize the approach to persons with elevated alanine aminotransferase levels (ALT) during therapy
- Define sustained virologic response
- Describe appropriate monitoring for patients after HCV treatment
- Quick ReferenceMonitoring During and After HCV Treatment Core Concepts
4Lesson 4 Treatment of HCV in Persons with Cirrhosis
- Learning Objectives
- Distinguish persons with compensated cirrhosis from those with decompensated cirrhosis
- Summarize the impact of treating HCV in persons with cirrhosis
- Discuss major studies involving regimens with pangenotypic activity used to treat HCV in persons with compensated cirrhosis
- Provide appropriate HCV treatment options for persons with compensated cirrhosis
- List approaches to treatment of HCV in persons with decompensated cirrhosis
- Quick ReferenceTreatment of HCV in Persons with Cirrhosis Core Concepts
- Activity 4B.Understanding Liver Biopsy Results
5Lesson 5 Treatment of Acute HCV Infection
- Learning Objectives
- Discuss HCV epidemiologic features of acute hepatitis C virus (HCV) infection in the United States
- Explain spontaneous HCV clearance after acute infection and its impact on treatment strategies
- Formulate an approach to evaluate and treat persons with acute HCV infection
- Describe timing for initiating treatment of persons with acute HCV infection
- Summarize recommendations for treatment regimens for persons with acute HCV infection
- Quick ReferenceTreatment of Acute HCV Infection Core Concepts
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CME provided byUniversity of Alabama Birmingham
CNE provided byUniversity of Washington School of Nursing
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