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Grading System Used for AASLD-IDSA Hepatitis C Guidance

ClassificationDescription
Class IConditions for which there is evidence and/or general agreement that a given diagnostic evaluation, procedure, or treatment is beneficial, useful, and effective
Class IIConditions for which there is conflicting evidence and/or a divergence of opinion about the usefulness and efficacy of a diagnostic evaluation, procedure, or treatment
Class IIaWeight of evidence and/or opinion is in favor of usefulness and efficacy
Class IIbUsefulness and efficacy are less well established by evidence and/or opinion
Class IIIConditions for which there is evidence and/or general agreement that a diagnostic evaluation, procedure, or treatment is not useful and effective or if it in some cases may be harmful
Level of EvidenceDescription
Level AData derived from multiple randomized clinical trials or meta-analyses
Level BData derived from a single randomized trial, or nonrandomized studies
Level CConsensus opinion of experts, case studies, or standard of care

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