NS4B
Nonstructural protein 4B (NS4B) is a protein that induces alternations in the cytoplasmic membrane and mediates virus-host interactions; this protein co-localizes to the endoplasmic reticulum, along with other non-structural proteins, to forms the replication complex. The NS4B protein is one of several viral components essential to the formation of the membranous web, a microenvironment within the cytoplasm that supports viral replication.