Activity 2B. GFR Calculator PDF Share Learning Objective Performance Indicators Explain the impact of HCV on renal disease Summarize the main findings from HCV treatment studies in people with renal disease Discuss dosing of direct-acting antiviral medications in persons with chronic renal disease Describe appropriate HCV treatment in persons prior to renal transplantaton Summarize HCV treatment recommendations in persons following renal transplantation InstructionsA 55-year-old woman is seen to begin therapy for chronic HCV genotype 2 infection. She is African-American and her weight is 61 kg. Her serum creatinine is 1.27 mg/dL. Using the GFR Calculator tool below (which can also be found by clicking on the Clinical Calculators tab in the top navigation bar), obtain an estimate of this patient's GFR and then answer the Activity Question below.2021 CKD-EPI Creatine-Cystatin C Share Sex: Male Female Age (years): Serum creatinine (mg/dL): You can provide the serum creatinine, serum cystatin c, or both. + Serum cystatin C (mg/L): You can provide the serum creatinine, serum cystatin c, or both. + eGFRcr:eGFRcr-cys:eGFRcys:mL/min/1.73 m2 CKD-EPI Adult eGFR Equation Depending on which variables are provided, one of the following equations will be utilized: eGFRcr = 142 × min(SCr/κ,1)α × max(SCr/κ,1)-1.2 × 0.9938Age × 1.012 (if female) κ = 0.7 (females) or 0.9 (males) α = -0.241 (females) or -0.302 (males) eGFRcys = 133 × min(Scys/0.8,1)-0.499 × max(SCr/0.8,1)-1.328 × 0.996Age × 0.932 (if female) eGFRcr-cys = 135 × min(SCr/κ,1)α × max(SCr/κ,1)-0.544 × min(Scys/0.8,1)-0.323 × max(Scys/0.8,1)-0.778 × 0.9961Age × 0.963 (if female) κ = 0.7 (females) or 0.9 (males) α = -0.219 (females) or -0.144 (males) Notes: This Chronic Kidney Disease Epidemiology (CKD-EPI) calculator is for adults (people ages 18 and older). This calculator uses the race-free 2021 CKD-EPI equations to estimate GFR. The development of this calculator was led by Dr. Andrew S. Levy and Dr. Lesley A. Inker. Cystatin C is not available in all laboratories and most patients can be monitored with serum creatinine alone. Sources Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999;130:461-70. Levey AS, Coresh J, Greene T, et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med. 2006;145:247-54. Related ActivitiesYou may find more information and a scenario for which you can use this calculator in the following activities from our curriculum:GFR CalculatorGFR CalculatorGFR Calculator This calculator operates entirely from your device. No input variables or data is transmitted between your computer and our servers. Share by e-mail From:Enter your e-mail address To: Enter the e-mail address of the recipient Your Message: View all Clinical Calculators Activity QuestionYou should answer this question after completing the activity. You must answer all of the questions before checking your work. What is this woman's estimated GFR? 32 mL/min/1.73m2 43 mL/min/1.73m2 50 mL/min/1.73m2 64 mL/min/1.73m2 Share by e-mail From:Enter your e-mail address To: Enter the e-mail address of the recipient Your Message: Check-On-LearningQuestionsThe Check-on-Learning Questions are short and topic related. They are meant to help you stay on track throughout each lesson and check your understanding of key concepts.You must be signed in to customize your interaction with these questions.
