Treatment of Hepatitis C Infection

Self-StudyTreatment of Hepatitis C Infection

Treatment of Hepatitis C
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Treatment of Hepatitis C

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Core Competencies

Simplified HCV Treatment for All HCV Genotypes

Topic
Learning Objectives
Introduction
Eligibility for Simplified HCV Treatment: Initial Assessment
Simplified Treatment: Pretreatment Assessment for Patients without Cirrhosis
Recommended Simplified Treatment Regimens for Patients without Cirrhosis
Monitoring on and after HCV Treatment in Patients without Cirrhosis
Simplified Treatment: Pretreatment Assessment for Patients with Compensated Cirrhosis
Recommended Simplified Treatment Regimens for Patients with Compensated Cirrhosis
Monitoring On and After Treatment for Patients with Compensated Cirrhosis
Treatment Interruptions
Summary Points

Retreatment of Patients with Prior HCV Treatment Experience

Topic
Learning Objectives
Introduction
Special Considerations with Retreatment
Treatment Failure with Sofosbuvir-Containing DAA or Elbasvir-Grazoprevir
Treatment Failure with Glecaprevir-Pibrentasvir
Treatment Failure with Multiple DAA Regimens
Summary Points

Monitoring During and After HCV Treatment

Topic
Learning Objectives
Background
Monitoring for Treatment Efficacy
Monitoring for Safety at Baseline and During Treatment
Hepatitis B Reactivation Associated with HCV DAA Therapy
Monitoring After Receiving HCV Therapy
Summary Points

Treatment of HCV in Persons with Cirrhosis

Topic
Learning Objectives
Background
Impact of Treating HCV in Persons with Cirrhosis
Treating HCV in Persons with Compensated Cirrhosis
Treating HCV in Persons with Decompensated Cirrhosis
Summary Points

Treatment of Acute HCV Infection

Topic
Learning Objectives
Background
Spontaneous Clearance of HCV Following Acute Infection
Comprehensive Clinical Care during Workup for Acute HCV
Acute HCV Treatment Data
AASLD-IDSA Guidance for Management of Acute HCV
Summary Points

Self-Study Module Progress Tracker - 4th Edition

Lesson 1Simplified HCV Treatment for All HCV Genotypes
  • Summarize the eligibility criteria for the American Association for the Study of Liver Disease/Infectious Diseases Society of America (AASLD/IDSA) simplified HCV treatment algorithm
  • Discuss how to assess liver fibrosis, including identifying decompensated cirrhosis
  • List the direct-acting antiviral (DAA) treatment regimens recommended as part of the AASLD/IDSA simplified guidance
  • Describe on-treatment monitoring for adults during HCV treatment using the simplified AASLD/IDSA guidance
  • Describe appropriate post-treatment monitoring for adults after completing HCV treatment
Lesson 2Retreatment of Patients with Prior HCV Treatment Experience
  • Discuss the approach to retreatment of patients with chronic hepatitis C in the direct-acting antiviral (DAA) era
  • List the preferred therapeutic combinations for retreatment in persons with prior sofosbuvir-containing regimens
  • Describe recommended options for retreatment in persons with prior treatment with elbasvir-grazoprevir
  • Review preferred retreatment options for persons with prior treatment with glecaprevir-pibrentasvir
  • Summarize options for persons with multiple prior DAA treatment failures
Lesson 3Monitoring During and After HCV Treatment
  • List the recommended monitoring for treatment efficacy and safety in adults receiving HCV therapy
  • Discuss monitoring for hepatitis B virus reactivation during HCV therapy
  • Summarize the approach to persons with elevated alanine aminotransferase levels (ALT) during therapy
  • Define sustained virologic response
  • Describe appropriate monitoring for patients after HCV treatment
Lesson 4Treatment of HCV in Persons with Cirrhosis
  • Distinguish persons with compensated cirrhosis from those with decompensated cirrhosis
  • Summarize the impact of treating HCV in persons with cirrhosis
  • Discuss major studies involving regimens with pangenotypic activity used to treat HCV in persons with compensated cirrhosis
  • Provide appropriate HCV treatment options for persons with compensated cirrhosis
  • List approaches to treatment of HCV in persons with decompensated cirrhosis
Lesson 5Treatment of Acute HCV Infection
  • Discuss HCV epidemiologic features of acute hepatitis C virus (HCV) infection in the United States
  • Explain spontaneous HCV clearance after acute infection and its impact on treatment strategies
  • Formulate an approach to evaluate and treat persons with acute HCV infection
  • Describe timing for initiating treatment of persons with acute HCV infection
  • Summarize recommendations for treatment regimens for persons with acute HCV infection
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CE Quiz 
 
 
 
 

Self-Study Module Progress Tracker - 3rd Edition

3rd Edition. There is a newer edition of this Self-Study Module.
Lesson 1Genotype 1
3rd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (3rd).
  • List key factors that influence the choice and duration of therapy for treating HCV genotype 1 infection
  • Describe the circumstances for NS5A genotypic drug resistance testing
  • Discuss preferred therapies for initial treatment of treatment-naïve adults with HCV genotype 1 infection
  • List the preferred therapies for retreatment of adults with chronic HCV genotype 1 infection who have previously failed therapy
Lesson 2Genotype 2
3rd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (3rd).
  • List preferred therapies for initial treatment of adults with HCV genotype 2 chronic infection
  • Describe the preferred therapy for retreatment of adults with HCV genotype 2 chronic infection who have failed prior therapy
Lesson 3Genotype 3
3rd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (3rd).
  • List preferred therapies for initial treatment of adults with HCV genotype 3 chronic infection
  • Describe the preferred therapy for retreatment of adults with HCV genotype 3 chronic infection who have failed prior therapy
Lesson 4Genotype 4
3rd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (3rd).
  • Understand the preferred therapies for the initial treatment of adults with HCV genotype 4 chronic infection
  • State the preferred therapy for retreatment of adults with HCV genotype 4 chronic infection in whom prior therapy has failed
Lesson 5Genotype 5 or 6
3rd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (3rd).
  • List the preferred therapies for the initial treatment of adults with HCV genotype 5 or 6 chronic infection
  • Discuss the preferred approach to retreatment of adults with HCV genotype 5 or 6 chronic infection who have failed prior therapy
Lesson 6Monitoring
3rd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (3rd).
  • List the recommended monitoring for treatment efficacy and safety in adults receiving HCV therapy
  • Discuss monitoring for hepatitis B virus reactivation during HCV therapy
  • Summarize appropriate monitoring for patients after HCV treatment
Topic 1 
 
 
 
 
 
Topic 2 
 
 
 
 
 
Topic 3 
 
 
 
 
 
Topic 4 
 
 
 
 
 
Topic 5 
 
 
 
 
 
Topic 6 
 
 
 
 
 
CE Quiz 
 
 
 
 
 

Self-Study Module Progress Tracker - 2nd Edition

2nd Edition. There is a newer edition of this Self-Study Module.
Lesson 1Genotype 1
3rd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (3rd).
  • List key factors that influence the choice and duration of therapy for treating HCV genotype 1 infection
  • Describe the circumstances for NS5A genotypic drug resistance testing
  • Discuss preferred therapies for initial treatment of treatment-naïve adults with HCV genotype 1 infection
  • List the preferred therapies for retreatment of adults with chronic HCV genotype 1 infection who have previously failed therapy
Lesson 2Genotype 2
3rd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (3rd).
  • List preferred therapies for initial treatment of adults with HCV genotype 2 chronic infection
  • Describe the preferred therapy for retreatment of adults with HCV genotype 2 chronic infection who have failed prior therapy
Lesson 3Genotype 3
3rd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (3rd).
  • List preferred therapies for initial treatment of adults with HCV genotype 3 chronic infection
  • Describe the preferred therapy for retreatment of adults with HCV genotype 3 chronic infection who have failed prior therapy
Lesson 4Genotype 4
3rd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (3rd).
  • Understand the preferred therapies for the initial treatment of adults with HCV genotype 4 chronic infection
  • State the preferred therapy for retreatment of adults with HCV genotype 4 chronic infection in whom prior therapy has failed
Lesson 5Genotype 5 or 6
3rd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (3rd).
  • List the preferred therapies for the initial treatment of adults with HCV genotype 5 or 6 chronic infection
  • Discuss the preferred approach to retreatment of adults with HCV genotype 5 or 6 chronic infection who have failed prior therapy
Lesson 6Monitoring
3rd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (3rd).
  • List the recommended monitoring for treatment efficacy and safety in adults receiving HCV therapy
  • Discuss monitoring for hepatitis B virus reactivation during HCV therapy
  • Summarize appropriate monitoring for patients after HCV treatment
Topic 1 
 
 
 
 
 
Topic 2 
 
 
 
 
 
Topic 3 
 
 
 
 
 
Topic 4 
 
 
 
 
 
Topic 5 
 
 
 
 
 
Topic 6 
 
 
 
 
 
CE Quiz 
 
 
 
 
 

Self-Study Module Progress Tracker - 1st Edition

1st Edition. There is a newer edition of this Self-Study Module.
Lesson 1Genotype 1
3rd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (3rd).
  • List key factors that influence the choice and duration of therapy for treating HCV genotype 1 infection
  • Describe the circumstances for NS5A genotypic drug resistance testing
  • Discuss preferred therapies for initial treatment of treatment-naïve adults with HCV genotype 1 infection
  • List the preferred therapies for retreatment of adults with chronic HCV genotype 1 infection who have previously failed therapy
Lesson 2Genotype 2
3rd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (3rd).
  • List preferred therapies for initial treatment of adults with HCV genotype 2 chronic infection
  • Describe the preferred therapy for retreatment of adults with HCV genotype 2 chronic infection who have failed prior therapy
Lesson 3Genotype 3
3rd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (3rd).
  • List preferred therapies for initial treatment of adults with HCV genotype 3 chronic infection
  • Describe the preferred therapy for retreatment of adults with HCV genotype 3 chronic infection who have failed prior therapy
Lesson 4Genotype 4
3rd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (3rd).
  • Understand the preferred therapies for the initial treatment of adults with HCV genotype 4 chronic infection
  • State the preferred therapy for retreatment of adults with HCV genotype 4 chronic infection in whom prior therapy has failed
Lesson 5Genotype 5 or 6
3rd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (3rd).
  • List the preferred therapies for the initial treatment of adults with HCV genotype 5 or 6 chronic infection
  • Discuss the preferred approach to retreatment of adults with HCV genotype 5 or 6 chronic infection who have failed prior therapy
Lesson 6Monitoring
3rd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (3rd).
  • List the recommended monitoring for treatment efficacy and safety in adults receiving HCV therapy
  • Discuss monitoring for hepatitis B virus reactivation during HCV therapy
  • Summarize appropriate monitoring for patients after HCV treatment
Topic 1 
 
 
 
 
 
Topic 2 
 
 
 
 
 
Topic 3 
 
 
 
 
 
Topic 4 
 
 
 
 
 
Topic 5 
 
 
 
 
 
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CE Quiz 
 
 
 
 
 

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